05. Mar 2021
Mechanism of action of olamkicept confirmed in patients
The Cluster of Excellence “Precision Medicine in Chronic Inflammation“ announced today that the mechanism of action of CONARIS‘ fusion protein olamkicept was confirmed in patients with inflammatory bowel diseases (press release in German, publication).
23. Mar 2020
CONARIS out-licenses release technology
CONARIS has out-licensed its proprietary release technology for improved availability of certain gut microbiome-modulating substances in exchange for single payments and revenue shares to an undisclosed global partner from the food industry.
10. Oct 2018
CONARIS out-licenses colonoscopy technology
CONARIS has out-licensed its proprietary colonoscopy technology for improved early detection of colon cancer in exchange for single payments and revenue shares to an undisclosed pharmaceutical partner.
14 Nov 2017
CONARIS sells filtration technology for stool transplantation
CONARIS has sold its proprietary filtration technology for stool transplantation (intestinal microenvironment transfer / fecal filtrate transfer) in exchange for single payments and revenue shares to an undisclosed German partner.
19 Dec 2016
Sublicensing of olamkicept (FE 999301) in Asia
CONARIS’ licensee Ferring Pharmaceuticals announced today that the Chinese biotechnology company IMAB will further advance the development of olamkicept (FE 999301) in Asia. (Ferring's press release)
17 Nov 2016
A new treatment option for Clostridium difficile infection
The results from a small pilot study with CONARIS’ proprietory filtration technology for stool transplantation were pre-published online in the leading journal Gastroenterology today. Fecal microbiota transplantation from healthy donors is currently the treatment of last resort for patients with recurrent Clostridium difficile infection (CDI), if antibiotics fail. In the present study, clinicians at the University Hospital Schleswig-Holstein (Kiel, Germany) and researchers at the Institute of Clinical Molecular Biology at Kiel University surprisingly demonstrated that CONARIS’ invention of sterile fecal filtrate transfer also led to gut microbiota improvement and rapid relief from CDI symptoms. Fecal filtrate transfer significantly reduces the risk of transferring unknown pathogens and fundamentally questions the current understanding of viable microbiota being the therapeutic principle of stool transplantation.
07 Jan 2015
More than 20 patents for the designer protein FE301 and further variants
After the grant of the patents for the lead substance FE301 in the United States on 25 November 2014 and in South Korea on 15 December 2014, more than 20 patents protecting the biologics programme of CONARIS have been issued.
13 Aug 2014
New research programme on the systems biology of interleukin-6
On 01 September 2014, the new BMBF research consortium InTraSig was started. InTraSig is coordinated by the systems biologist Prof. Fred Schaper from the University of Magdeburg and involves project partners from the universities of Magdeburg, Kiel and Düsseldorf (all in Germany). As the industrial partner of the consortium, CONARIS can commercialise the results of the systems biology analysis and modelling of the interleukin-6 signalling pathway, in particular for the FE301 project out-licensed to Ferring Pharmaceuticals. The German Federal Ministry of Education and Research (BMBF) funds the consortium with a total of 2.1 mEUR until 2017.
26 Jul 2013
Conaris strengthens sgp130 product portfolio by new patents
The international patent protection for the production and therapeutic use of sgp130Fc and corresponding variants was recently strengthened and expanded by the grant of further patents in Australia, Eurasia, the Ukraine and the U.S. In cooperation with the pharma company Ferring the lead substance FE301 is currently developed for the treatment of chronic inflammatory diseases.
13 Jul 2011
EPO grants patent for gp130 muteins with improved binding activity
The European Patent Office (EPO) announced the grant of a further gp130 patent (EP 2 212 347) claiming the production and use of new gp130 variants. These variants comprise certain mutations within their protein sequence, which render improved activity to bind to the soluble Interleukin-6/sInterleukin-6 receptor complex. These muteins may serve as back-up or follow-up compound for FE301 or could also be used in certain IL-6-driven niche indications.
14 Dec 2010
Three new patents granted in Japan, the US and Europe
One of the most important patents to protect optimized sgp130Fc variants has been granted by the European Patent Office on 8th September 2010 (Patent No. 1 873 166). And two additional fantastic news followed shortly afterwards: the grant of a patent for optimized sgp130 sequences in Japan on 29th September 2010 (Patent No. 465016) and last but not least the grant of a patent for soluble sgp130 variants in the United States on 14th December 2010 (Patent No. 8,851,182). “This means not only that we were able to reach the next milestone in the collaboration with our licensing partner Ferring, but also adds of further important steps to the development of our lead compound FE301”, says CEO Dr. Dirk Seegert.
23 Jun 2010
EPO grants new patent for sgp130Fc variants
Today the European Patent Office (EPO) in Munich announced the grant of a new patent for sgp130. This patent protects the production and therapeutic use of new variants of the sgp130 fusion molecule. “In contrast to our parental sgp130Fc protein, certain parts of the extracellular domain of gp130 have been replaced by optimized linkers” says Dr. Dirk Seegert, Chief Executive Officer of the Conaris Research Institute AG. These variants provide advantages regarding their simplified molecular structure and subsequently their improved production and purification properties.
19 May 2009
USPTO grants first sgp130Fc patent in the USA
The United States Patent and Trademark Office (USPTO) has issued the first sgp130 patent in the US. This patent claims PEGylated forms of CONARIS’ sgp130 proteins and their therapeutic use in several IL-6-driven diseases. Dr. Dirk Seegert (CEO): “After receiving the European patent grant for PEGylated sgp130 proteins in 2007, this new achievement represents another important milestone on the way into the world’s most important pharma market.”
07 May 2009
Conaris receives 1.6 Mio BMBF grant
Today CONARIS received a 1.6 M EUR grant from the Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung; BMBF) in line with the economic support program “Innovative therapies on molecular and cellular basis”. The project comprises toxicity studies which are relevant for a later IND filing and investigations on further target indications for sgp130Fc within the next 2 years. Collaboration partner is the Hannover Medical School (MHH, Germany). Dr. Dirk Seegert (CEO): “This grant is an important milestone for our work. We are very proud that we were able to convince the ministry about the quality of the project. This moves us significantly closer towards our aim, to start first clinical studies in 2011!”
10 Dec 2008
Conaris signs Licensing Agreement with Ferring Pharmaceuticals
Saint Prex (Switzerland) and Kiel (Germany), 10 December 2008 - Ferring Pharmaceuticals and Conaris Research Institute AG today announced that they have completed an exclusive worldwide license agreement for the development of FE301 a new recombinant protein inhibitor of the IL-6 pathway for inflammatory conditions such as IBD and rheumatoid arthritis.
12 Jun 2008
EPO grants patent for optimized cDNA sequences of sgp130Fc
The European Patent Office (EPO) grants a new patent (No. 1 630 232) in Europe claiming certain optimized cDNA sequences of CONARIS’ lead product sgp130Fc. These sequences improve the stability of the corresponding mRNA and increase the production rate of the protein in CHO cells.
11 Sep 2007
EPO grants patent for PEGylated variants of sgp130Fc
The European Patent Office (EPO) grants a new patent (No. 1 636 263) in Europe claiming the production of PEGylated variants of sgp130 proteins and their use in therapeutic compositions for the treatment of inflammatory and certain oncologic indications.
22 Jun 2007
EPO grants core patent for sgp130Fc
The European Patent Office (EPO) grants a CONARIS key patent (No. 1 148 065) for its lead product sgp130Fc, an anti-inflammatory drug candidate, in Europe. The patent claims the nucleotide and polypeptide sequences of the product, certain procedures for its production and isolation and its use for the treatment of several severe chronic diseases.
06 Apr 2006
Conaris receives 1.3 Mio grant from the BMBF
CONARIS receives a 1.3 Mio EUR grant from the Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung; BMBF) for the preclinical development of its lead compound sgp130Fc.
08 Jul 2004
Conaris receives a 110.000 EUR grant from the BMBF
CONARIS receives a 110.000 EUR grant from the Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung; BMBF) for the development of a technological platform for the functional evaluation of new therapeutic drugs. This project is part of the National Genome Research Network 2 (NGFN2).
01 Feb 2003
Conaris moves into new laboratory
CONARIS moves into new laboratories and offices at the “Kieler Innovations- und Technologiezentrum” (KITZ).
01 Jan 2003
Stefan Rose-John appointed as new member of Conaris’ Advisory Board
Prof. Stefan Rose-John (Director of the Institute of Biochemistry, Christian-Albrechts-University of Kiel) becomes new member of CONARIS’ Advisory Board and replaces Hans-Ulrich Behr. Stefan Rose-John has been working on the investigation of IL-6-mediated signaling processes for more than 15 years. He designed the first sgp130 fusion protein and performed pioneer studies to discover IL-6-induced transsignaling.
19 Nov 2002
Conaris receives a 910.000 EUR grant from the BMBF
CONARIS receives a 910.000 EUR grant from the Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung; BMBF) for the development of inflammation-specific cDNA and protein arrays together with the biochip company SCIENION AG (Berlin).
01 Jul 2002
Dirk Seegert appointed as new CEO of Conaris
Dr. Dirk Seegert becomes new CEO/CSO of CONARIS. Before, he headed the Cell Biology Laboratory, Mucosal Immunology, Department of Internal Medicine, University Hospital Schleswig-Holstein (UK-SH), Campus Kiel. The main focus of his work was on inflammation-associated signaling mechanisms. During this time, he was involved in the biological characterization of different new IBD markers.
30 May 2002
New members of the Conaris Advisory Board
Prof. Stefan Schreiber, Prof. Gerhard Steinmann and Hans-Ulrich Behr are nominated as members of CONARIS’ Advisory Board.